Drug from one of five in Spain Crossword Clue

The crossword clue "Drug from one of five in Spain" with the answer "QUININE" refers to the substance quinine, a medication used primarily to treat malaria. The clue plays on the Spanish word for "five," which is "cinco."

In Spanish, "quin" is a root that relates to "five," and "quinine" derives from "quina," which is Spanish for cinchona bark—the source of quinine. This wordplay cleverly connects the drug’s name to its origins and its numerical hint.

The crossword clue "Drug from one of five in Spain" with the answer "QUIBBLE" refers to a clever play on words that combines elements of both geography and language. In this clue, "Drug" serves as a misdirection, implying a pharmaceutical substance.

However, the solution "QUIBBLE" is derived from the wordplay involving the Spanish language and numbers. The phrase "one of five in Spain" hints at the fact that the answer contains the name of one of the five vowels in the Spanish alphabet.

The crossword clue "Drug from one of five in Spain" with the answer "QUICKIE" refers to a playful and somewhat cryptic wordplay that combines multiple elements. In this case, "QUICKIE" is not directly related to a literal drug but rather to a pun or a clever twist in crossword puzzle clues.

The "five in Spain" part of the clue could be hinting at the number "5" or something associated with it in Spanish. In this context, "QUICKIE" is used as slang for a brief or hasty activity, which can be interpreted as a "quick fix" or a rapid solution—similar to the idea of a quick, informal drug or remedy. 

The crossword clue "Drug from one of five in Spain" with the answer "QUIXOTE" refers to the Spanish novel Don Quixote by Miguel de Cervantes. In this clue, "Drug" is a play on the word "quixote" because the term "quixote" is associated with a sense of delusion or fantasy, which can be metaphorically linked to the effects of a drug.

The phrase "one of five in Spain" alludes to the famous Spanish literary figure, Don Quixote, who is one of the most iconic characters in Spanish literature.